我想将表达水平值转换为z-score（mean-x / sd）。我的微阵列中有两种类型的样品（Affymetrix GeneChip Human Genome U133 Plus 2.0）（正常与病例）我是否必须仅计算正常样本的平均值和sd，并使用z-score公式然后对案例样本或我必须找到整个样本的均值和sd？
ID_REF Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Normal Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic Diabetic
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