三个治疗组的生存功能输出差异

时间:2018-09-03 06:28:56

标签: r survival-analysis weibull survival

(跳到底部以获取更新以及新的代码和数据)

我正在尝试绘制带有间隔检查器数据的生存曲线。尽管我不确定是否正确编码了事件,例如是否应该使用1,但我已经能够使用间隔检查器数据成功绘制了生存曲线(如下所示)。

这是我用来生成生存曲线的代码。

simafit <- survfit(Surv(Time1, Time2, Event, type = c('interval')) ~ 
Treatment, data = sima)

ggsurvplot(simafit, conf.int = TRUE, 
legend.labs=c("Control","Drought","Water+"), ggtheme = theme_bw(), 
legend.title = "Treatment", title ="Sidalcea malviflora", palette = 
c("gray47","orangered","deepskyblue"),xlim=c(0,838), ylim=c(0,1), xlab="Days 
Since Planting")+scale_x_continuous(expand = c(0, 0)) + 
scale_y_continuous(expand = c(0, 0))

survival plot

接下来,我尝试使用survreg函数测试处理之间的差异并获取p值。

这是我的代码:

survreg(Surv(Time1d, Time2d, Event, type = c('interval')) ~ Treatment,
        dist="weibull", data = sima)

但我不断收到错误消息:

    Error in survreg(Surv(Time1d, Time2d, Event, type = c("interval")) ~ Treatment,  : 
Invalid survival times for this distribution

我最初尝试使用Time1和Time2,但是后来我看到0在函数中不起作用,所以我做了一个额外的副本进行测试。我尝试过以多种不同的方式显示数据,但找不到与survreg一起使用的数据,但此格式与ggsurvplot一起使用时效果很好,但是两个函数的格式可能需要不同?

感谢您的帮助。

以下是数据:

    Plot ID Subplot Treatment   Column  Row Species Time1   Time2   Event   Time1d  Time2d
    PS1 1   shelter A   7   SIMA    Inf 0   0   1   1
    PS1 2   shelter C   2   SIMA    Inf 0   0   1   1
    PS1 3   shelter D   2   SIMA    Inf 0   0   1   1
    PS2 1   shelter A   7   SIMA    Inf 0   0   1   1
    PS2 2   shelter C   2   SIMA    Inf 0   0   1   1
    PS2 3   shelter D   2   SIMA    Inf 0   0   1   1
    PS3 1   shelter A   7   SIMA    Inf 0   0   1   1
    PS3 2   shelter C   2   SIMA    Inf 0   0   1   1
    PS3 3   shelter D   2   SIMA    Inf 0   0   1   1
    PS4 1   shelter A   7   SIMA    Inf 0   0   1   1
    PS4 2   shelter C   2   SIMA    Inf 0   0   1   1
    PS4 3   shelter D   2   SIMA    Inf 0   0   1   1
    PS5 1   shelter A   7   SIMA    Inf 0   0   1   1
    PS5 2   shelter C   2   SIMA    Inf 0   0   1   1
    PS5 3   shelter D   2   SIMA    Inf 0   0   1   1
    PC1 1   control A   7   SIMA    Inf 0   0   1   1
    PC1 2   control C   2   SIMA    Inf 0   0   1   1
    PC1 3   control D   2   SIMA    Inf 0   0   1   1
    PC2 1   control A   7   SIMA    Inf 0   0   1   1
    PC2 2   control C   2   SIMA    Inf 0   0   1   1
    PC2 3   control D   2   SIMA    Inf 0   0   1   1
    PC3 1   control A   7   SIMA    Inf 0   0   1   1
    PC3 2   control C   2   SIMA    Inf 0   0   1   1
    PC3 3   control D   2   SIMA    Inf 0   0   1   1
    PC4 1   control A   7   SIMA    Inf 0   0   1   1
    PC4 2   control C   2   SIMA    Inf 0   0   1   1
    PC4 3   control D   2   SIMA    Inf 0   0   1   1
    PC5 1   control A   7   SIMA    Inf 0   0   1   1
    PC5 2   control C   2   SIMA    Inf 0   0   1   1
    PC5 3   control D   2   SIMA    Inf 0   0   1   1
    PW1 1   watered A   7   SIMA    Inf 0   0   1   1
    PW1 2   watered C   2   SIMA    Inf 0   0   1   1
    PW1 3   watered D   2   SIMA    Inf 0   0   1   1
    PW2 1   watered A   7   SIMA    Inf 0   0   1   1
    PW2 2   watered C   2   SIMA    Inf 0   0   1   1
    PW2 3   watered D   2   SIMA    Inf 0   0   1   1
    PW3 1   watered A   7   SIMA    Inf 0   0   1   1
    PW3 2   watered C   2   SIMA    Inf 0   0   1   1
    PW3 3   watered D   2   SIMA    Inf 0   0   1   1
    PW4 1   watered A   7   SIMA    Inf 0   0   1   1
    PW4 2   watered C   2   SIMA    Inf 0   0   1   1
    PW4 3   watered D   2   SIMA    Inf 0   0   1   1
    PW5 1   watered A   7   SIMA    Inf 0   0   1   1
    PW5 2   watered C   2   SIMA    Inf 0   0   1   1
    PW5 3   watered D   2   SIMA    Inf 0   0   1   1
    PS1 1   shelter A   7   SIMA    0   26  0   1   26
    PS1 2   shelter C   2   SIMA    0   26  0   1   26
    PS1 3   shelter D   2   SIMA    0   26  0   1   26
    PS2 1   shelter A   7   SIMA    0   26  0   1   26
    PS2 2   shelter C   2   SIMA    0   26  0   1   26
    PS2 3   shelter D   2   SIMA    0   26  0   1   26
    PS3 1   shelter A   7   SIMA    0   26  0   1   26
    PS3 2   shelter C   2   SIMA    0   26  0   1   26
    PS3 3   shelter D   2   SIMA    0   26  0   1   26
    PS4 1   shelter A   7   SIMA    0   26  0   1   26
    PS4 2   shelter C   2   SIMA    0   26  0   1   26
    PS4 3   shelter D   2   SIMA    0   26  0   1   26
    PS5 1   shelter A   7   SIMA    0   26  0   1   26
    PS5 2   shelter C   2   SIMA    0   26  0   1   26
    PS5 3   shelter D   2   SIMA    0   26  0   1   26
    PC1 1   control A   7   SIMA    0   26  0   1   26
    PC1 2   control C   2   SIMA    0   26  0   1   26
    PC1 3   control D   2   SIMA    0   26  0   1   26
    PC2 1   control A   7   SIMA    0   26  0   1   26
    PC2 2   control C   2   SIMA    0   26  0   1   26
    PC2 3   control D   2   SIMA    0   26  0   1   26
    PC3 1   control A   7   SIMA    0   26  0   1   26
    PC3 2   control C   2   SIMA    0   26  0   1   26
    PC3 3   control D   2   SIMA    0   26  0   1   26
    PC4 1   control A   7   SIMA    0   26  0   1   26
    PC4 2   control C   2   SIMA    0   26  0   1   26
    PC4 3   control D   2   SIMA    0   26  0   1   26
    PC5 1   control A   7   SIMA    0   26  1   1   26
    PC5 2   control C   2   SIMA    0   26  0   1   26
    PC5 3   control D   2   SIMA    0   26  0   1   26
    PW1 1   watered A   7   SIMA    0   26  0   1   26
    PW1 2   watered C   2   SIMA    0   26  0   1   26
    PW1 3   watered D   2   SIMA    0   26  0   1   26
    PW2 1   watered A   7   SIMA    0   26  0   1   26
    PW2 2   watered C   2   SIMA    0   26  0   1   26
    PW2 3   watered D   2   SIMA    0   26  0   1   26
    PW3 1   watered A   7   SIMA    0   26  0   1   26
    PW3 2   watered C   2   SIMA    0   26  0   1   26
    PW3 3   watered D   2   SIMA    0   26  0   1   26
    PW4 1   watered A   7   SIMA    0   26  0   1   26
    PW4 2   watered C   2   SIMA    0   26  0   1   26
    PW4 3   watered D   2   SIMA    0   26  0   1   26
    PW5 1   watered A   7   SIMA    0   26  0   1   26
    PW5 2   watered C   2   SIMA    0   26  0   1   26
    PW5 3   watered D   2   SIMA    0   26  0   1   26
    PS1 1   shelter A   7   SIMA    26  92  0   26  92
    PS1 2   shelter C   2   SIMA    26  92  0   26  92
    PS1 3   shelter D   2   SIMA    26  92  0   26  92
    PS2 1   shelter A   7   SIMA    26  92  0   26  92
    PS2 2   shelter C   2   SIMA    26  92  0   26  92
    PS2 3   shelter D   2   SIMA    26  92  0   26  92
    PS3 1   shelter A   7   SIMA    26  92  0   26  92
    PS3 2   shelter C   2   SIMA    26  92  0   26  92
    PS3 3   shelter D   2   SIMA    26  92  0   26  92
    PS4 1   shelter A   7   SIMA    26  92  0   26  92
    PS4 2   shelter C   2   SIMA    26  92  0   26  92
    PS4 3   shelter D   2   SIMA    26  92  0   26  92
    PS5 1   shelter A   7   SIMA    26  92  0   26  92
    PS5 2   shelter C   2   SIMA    26  92  0   26  92
    PS5 3   shelter D   2   SIMA    26  92  0   26  92
    PC1 1   control A   7   SIMA    26  92  0   26  92
    PC1 2   control C   2   SIMA    26  92  0   26  92
    PC1 3   control D   2   SIMA    26  92  0   26  92
    PC2 1   control A   7   SIMA    26  92  0   26  92
    PC2 2   control C   2   SIMA    26  92  0   26  92
    PC2 3   control D   2   SIMA    26  92  0   26  92
    PC3 1   control A   7   SIMA    26  92  0   26  92
    PC3 2   control C   2   SIMA    26  92  0   26  92
    PC4 1   control A   7   SIMA    26  92  0   26  92
    PC4 2   control C   2   SIMA    26  92  0   26  92
    PC4 3   control D   2   SIMA    26  92  0   26  92
    PC5 1   control A   7   SIMA    26  92  3   26  92
    PC5 2   control C   2   SIMA    26  92  0   26  92
    PC5 3   control D   2   SIMA    26  92  0   26  92
    PW1 1   watered A   7   SIMA    26  92  0   26  92
    PW1 2   watered C   2   SIMA    26  92  0   26  92
    PW1 3   watered D   2   SIMA    26  92  0   26  92
    PW2 1   watered A   7   SIMA    26  92  0   26  92
    PW2 2   watered C   2   SIMA    26  92  0   26  92
    PW2 3   watered D   2   SIMA    26  92  0   26  92
    PW3 1   watered A   7   SIMA    26  92  0   26  92
    PW3 2   watered C   2   SIMA    26  92  0   26  92
    PW3 3   watered D   2   SIMA    26  92  0   26  92
    PW4 1   watered A   7   SIMA    26  92  0   26  92
    PW4 2   watered C   2   SIMA    26  92  0   26  92
    PW4 3   watered D   2   SIMA    26  92  0   26  92
    PW5 1   watered A   7   SIMA    26  92  0   26  92
    PW5 2   watered C   2   SIMA    26  92  0   26  92
    PW5 3   watered D   2   SIMA    26  92  0   26  92
    PS1 1   shelter A   7   SIMA    92  120 0   92  120
    PS1 2   shelter C   2   SIMA    92  120 0   92  120
    PS1 3   shelter D   2   SIMA    92  120 0   92  120
    PS2 1   shelter A   7   SIMA    92  120 0   92  120
    PS2 2   shelter C   2   SIMA    92  120 0   92  120
    PS2 3   shelter D   2   SIMA    92  120 0   92  120
    PS3 1   shelter A   7   SIMA    92  120 0   92  120
    PS3 2   shelter C   2   SIMA    92  120 0   92  120
    PS3 3   shelter D   2   SIMA    92  120 0   92  120
    PS4 1   shelter A   7   SIMA    92  120 0   92  120
    PS4 2   shelter C   2   SIMA    92  120 0   92  120
    PS4 3   shelter D   2   SIMA    92  120 0   92  120
    PS5 1   shelter A   7   SIMA    92  120 0   92  120
    PS5 2   shelter C   2   SIMA    92  120 0   92  120
    PS5 3   shelter D   2   SIMA    92  120 0   92  120
    PC1 1   control A   7   SIMA    92  120 0   92  120
    PC1 2   control C   2   SIMA    92  120 0   92  120
    PC1 3   control D   2   SIMA    92  120 0   92  120
    PC2 1   control A   7   SIMA    92  120 0   92  120
    PC2 2   control C   2   SIMA    92  120 0   92  120
    PC2 3   control D   2   SIMA    92  120 0   92  120
    PC3 1   control A   7   SIMA    92  120 0   92  120
    PC3 2   control C   2   SIMA    92  120 0   92  120
    PC3 3   control D   2   SIMA    92  120 0   92  120
    PC4 1   control A   7   SIMA    92  120 0   92  120
    PC4 2   control C   2   SIMA    92  120 1   92  120
    PC4 3   control D   2   SIMA    92  120 1   92  120
    PC5 1   control A   7   SIMA    92  120 2   92  120
    PC5 2   control C   2   SIMA    92  120 0   92  120
    PC5 3   control D   2   SIMA    92  120 0   92  120
    PW1 1   watered A   7   SIMA    92  120 0   92  120
    PW1 2   watered C   2   SIMA    92  120 0   92  120
    PW1 3   watered D   2   SIMA    92  120 0   92  120
    PW2 1   watered A   7   SIMA    92  120 0   92  120
    PW2 2   watered C   2   SIMA    92  120 0   92  120
    PW2 3   watered D   2   SIMA    92  120 0   92  120
    PW3 1   watered A   7   SIMA    92  120 0   92  120
    PW3 2   watered C   2   SIMA    92  120 1   92  120
    PW3 3   watered D   2   SIMA    92  120 0   92  120
    PW4 1   watered A   7   SIMA    92  120 1   92  120
    PW4 2   watered C   2   SIMA    92  120 0   92  120
    PW4 3   watered D   2   SIMA    92  120 0   92  120
    PW5 1   watered A   7   SIMA    92  120 0   92  120
    PW5 2   watered C   2   SIMA    92  120 0   92  120
    PW5 3   watered D   2   SIMA    92  120 0   92  120
    PS1 1   shelter A   7   SIMA    120 152 0   120 152
    PS1 2   shelter C   2   SIMA    120 152 0   120 152
    PS1 3   shelter D   2   SIMA    120 152 0   120 152
    PS2 1   shelter A   7   SIMA    120 152 0   120 152
    PS2 2   shelter C   2   SIMA    120 152 0   120 152
    PS2 3   shelter D   2   SIMA    120 152 0   120 152
    PS3 1   shelter A   7   SIMA    120 152 0   120 152
    PS3 2   shelter C   2   SIMA    120 152 1   120 152
    PS3 3   shelter D   2   SIMA    120 152 0   120 152
    PS4 1   shelter A   7   SIMA    120 152 0   120 152
    PS4 2   shelter C   2   SIMA    120 152 0   120 152
    PS4 3   shelter D   2   SIMA    120 152 0   120 152
    PS5 1   shelter A   7   SIMA    120 152 1   120 152
    PS5 2   shelter C   2   SIMA    120 152 0   120 152
    PS5 3   shelter D   2   SIMA    120 152 0   120 152
    PC1 1   control A   7   SIMA    120 152 0   120 152
    PC1 2   control C   2   SIMA    120 152 0   120 152
    PC1 3   control D   2   SIMA    120 152 0   120 152
    PC2 1   control A   7   SIMA    120 152 0   120 152
    PC2 2   control C   2   SIMA    120 152 0   120 152
    PC2 3   control D   2   SIMA    120 152 0   120 152
    PC3 1   control A   7   SIMA    120 152 1   120 152
    PC3 2   control C   2   SIMA    120 152 1   120 152
    PC3 3   control D   2   SIMA    120 152 1   120 152
    PC4 1   control A   7   SIMA    120 152 1   120 152
    PC4 2   control C   2   SIMA    120 152 3   120 152
    PC4 3   control D   2   SIMA    120 152 3   120 152
    PC5 1   control A   7   SIMA    120 152 2   120 152
    PC5 2   control C   2   SIMA    120 152 1   120 152
    PC5 3   control D   2   SIMA    120 152 0   120 152
    PW1 1   watered A   7   SIMA    120 152 0   120 152
    PW1 2   watered C   2   SIMA    120 152 0   120 152
    PW1 3   watered D   2   SIMA    120 152 0   120 152
    PW2 1   watered A   7   SIMA    120 152 0   120 152
    PW2 2   watered C   2   SIMA    120 152 0   120 152
    PW2 3   watered D   2   SIMA    120 152 0   120 152
    PW3 1   watered A   7   SIMA    120 152 1   120 152
    PW3 2   watered C   2   SIMA    120 152 3   120 152
    PW3 3   watered D   2   SIMA    120 152 1   120 152
    PW4 1   watered A   7   SIMA    120 152 3   120 152
    PW4 2   watered C   2   SIMA    120 152 0   120 152
    PW4 3   watered D   2   SIMA    120 152 1   120 152
    PW5 1   watered A   7   SIMA    120 152 0   120 152
    PW5 2   watered C   2   SIMA    120 152 0   120 152
    PW5 3   watered D   2   SIMA    120 152 0   120 152
    PS1 1   shelter A   7   SIMA    152 535 0   152 535
    PS1 2   shelter C   2   SIMA    152 535 0   152 535
    PS1 3   shelter D   2   SIMA    152 535 0   152 535
    PS2 1   shelter A   7   SIMA    152 535 0   152 535
    PS2 2   shelter C   2   SIMA    152 535 0   152 535
    PS2 3   shelter D   2   SIMA    152 535 0   152 535
    PS3 1   shelter A   7   SIMA    152 535 0   152 535
    PS3 2   shelter C   2   SIMA    152 535 3   152 535
    PS3 3   shelter D   2   SIMA    152 535 0   152 535
    PS4 1   shelter A   7   SIMA    152 535 0   152 535
    PS4 2   shelter C   2   SIMA    152 535 1   152 535
    PS4 3   shelter D   2   SIMA    152 535 0   152 535
    PS5 1   shelter A   7   SIMA    152 535 0   152 535
    PS5 2   shelter C   2   SIMA    152 535 1   152 535
    PS5 3   shelter D   2   SIMA    152 535 1   152 535
    PC1 1   control A   7   SIMA    152 535 1   152 535
    PC1 2   control C   2   SIMA    152 535 0   152 535
    PC1 3   control D   2   SIMA    152 535 1   152 535
    PC2 1   control A   7   SIMA    152 535 0   152 535
    PC2 2   control C   2   SIMA    152 535 0   152 535
    PC2 3   control D   2   SIMA    152 535 1   152 535
    PC3 1   control A   7   SIMA    152 535 3   152 535
    PC3 2   control C   2   SIMA    152 535 0   152 535
    PC3 3   control D   2   SIMA    152 535 0   152 535
    PC4 1   control A   7   SIMA    152 535 3   152 535
    PC4 2   control C   2   SIMA    152 535 2   152 535
    PC4 3   control D   2   SIMA    152 535 2   152 535
    PC5 1   control A   7   SIMA    152 535 2   152 535
    PC5 2   control C   2   SIMA    152 535 3   152 535
    PC5 3   control D   2   SIMA    152 535 0   152 535
    PW1 1   watered A   7   SIMA    152 535 0   152 535
    PW1 2   watered C   2   SIMA    152 535 0   152 535
    PW1 3   watered D   2   SIMA    152 535 0   152 535
    PW2 1   watered A   7   SIMA    152 535 0   152 535
    PW2 2   watered C   2   SIMA    152 535 0   152 535
    PW2 3   watered D   2   SIMA    152 535 0   152 535
    PW3 1   watered A   7   SIMA    152 535 3   152 535
    PW3 2   watered C   2   SIMA    152 535 2   152 535
    PW3 3   watered D   2   SIMA    152 535 3   152 535
    PW4 1   watered A   7   SIMA    152 535 2   152 535
    PW4 2   watered C   2   SIMA    152 535 0   152 535
    PW4 3   watered D   2   SIMA    152 535 3   152 535
    PW5 1   watered A   7   SIMA    152 535 0   152 535
    PW5 2   watered C   2   SIMA    152 535 1   152 535
    PW5 3   watered D   2   SIMA    152 535 0   152 535
    PS1 1   shelter A   7   SIMA    535 829 0   535 829
    PS1 2   shelter C   2   SIMA    535 829 1   535 829
    PS1 3   shelter D   2   SIMA    535 829 0   535 829
    PS2 1   shelter A   7   SIMA    535 829 0   535 829
    PS2 2   shelter C   2   SIMA    535 829 0   535 829
    PS2 3   shelter D   2   SIMA    535 829 0   535 829
    PS3 1   shelter A   7   SIMA    535 829 0   535 829
    PS3 2   shelter C   2   SIMA    535 829 0   535 829
    PS3 3   shelter D   2   SIMA    535 829 0   535 829
    PS4 1   shelter A   7   SIMA    535 829 0   535 829
    PS4 2   shelter C   2   SIMA    535 829 3   535 829
    PS4 3   shelter D   2   SIMA    535 829 0   535 829
    PS5 1   shelter A   7   SIMA    535 829 0   535 829
    PS5 2   shelter C   2   SIMA    535 829 0   535 829
    PS5 3   shelter D   2   SIMA    535 829 0   535 829
    PC1 1   control A   7   SIMA    535 829 3   535 829
    PC1 2   control C   2   SIMA    535 829 0   535 829
    PC1 3   control D   2   SIMA    535 829 3   535 829
    PC2 1   control A   7   SIMA    535 829 0   535 829
    PC2 2   control C   2   SIMA    535 829 1   535 829
    PC2 3   control D   2   SIMA    535 829 3   535 829
    PC3 1   control A   7   SIMA    535 829 2   535 829
    PC3 2   control C   2   SIMA    535 829 0   535 829
    PC3 3   control D   2   SIMA    535 829 0   535 829
    PC4 1   control A   7   SIMA    535 829 2   535 829
    PC4 2   control C   2   SIMA    535 829 2   535 829
    PC4 3   control D   2   SIMA    535 829 2   535 829
    PC5 1   control A   7   SIMA    535 829 2   535 829
    PC5 2   control C   2   SIMA    535 829 2   535 829
    PC5 3   control D   2   SIMA    535 829 1   535 829
    PW1 1   watered A   7   SIMA    535 829 1   535 829
    PW1 2   watered C   2   SIMA    535 829 0   535 829
    PW1 3   watered D   2   SIMA    535 829 0   535 829
    PW2 1   watered A   7   SIMA    535 829 0   535 829
    PW2 2   watered C   2   SIMA    535 829 0   535 829
    PW2 3   watered D   2   SIMA    535 829 1   535 829
    PW3 1   watered A   7   SIMA    535 829 0   535 829
    PW3 2   watered C   2   SIMA    535 829 2   535 829
    PW3 3   watered D   2   SIMA    535 829 0   535 829
    PW4 1   watered A   7   SIMA    535 829 2   535 829
    PW4 2   watered C   2   SIMA    535 829 1   535 829
    PW4 3   watered D   2   SIMA    535 829 2   535 829
    PW5 1   watered A   7   SIMA    535 829 1   535 829
    PW5 2   watered C   2   SIMA    535 829 0   535 829
    PW5 3   watered D   2   SIMA    535 829 0   535 829
    PS1 1   shelter A   7   SIMA    829 Inf 0   829 Inf
    PS1 2   shelter C   2   SIMA    829 Inf 3   829 Inf
    PS1 3   shelter D   2   SIMA    829 Inf 0   829 Inf
    PS2 1   shelter A   7   SIMA    829 Inf 0   829 Inf
    PS2 2   shelter C   2   SIMA    829 Inf 0   829 Inf
    PS2 3   shelter D   2   SIMA    829 Inf 0   829 Inf
    PS3 1   shelter A   7   SIMA    829 Inf 0   829 Inf
    PS3 2   shelter C   2   SIMA    829 Inf 0   829 Inf
    PS3 3   shelter D   2   SIMA    829 Inf 0   829 Inf
    PS4 1   shelter A   7   SIMA    829 Inf 0   829 Inf
    PS4 2   shelter C   2   SIMA    829 Inf 2   829 Inf
    PS4 3   shelter D   2   SIMA    829 Inf 0   829 Inf
    PS5 1   shelter A   7   SIMA    829 Inf 0   829 Inf
    PS5 2   shelter C   2   SIMA    829 Inf 0   829 Inf
    PS5 3   shelter D   2   SIMA    829 Inf 0   829 Inf
    PC1 1   control A   7   SIMA    829 Inf 2   829 Inf
    PC1 2   control C   2   SIMA    829 Inf 0   829 Inf
    PC1 3   control D   2   SIMA    829 Inf 2   829 Inf
    PC2 1   control A   7   SIMA    829 Inf 0   829 Inf
    PC2 2   control C   2   SIMA    829 Inf 3   829 Inf
    PC2 3   control D   2   SIMA    829 Inf 2   829 Inf
    PC3 1   control A   7   SIMA    829 Inf 2   829 Inf
    PC3 2   control C   2   SIMA    829 Inf 0   829 Inf
    PC3 3   control D   2   SIMA    829 Inf 0   829 Inf
    PC4 1   control A   7   SIMA    829 Inf 2   829 Inf
    PC4 2   control C   2   SIMA    829 Inf 2   829 Inf
    PC4 3   control D   2   SIMA    829 Inf 2   829 Inf
    PC5 1   control A   7   SIMA    829 Inf 2   829 Inf
    PC5 2   control C   2   SIMA    829 Inf 2   829 Inf
    PC5 3   control D   2   SIMA    829 Inf 3   829 Inf
    PW1 1   watered A   7   SIMA    829 Inf 3   829 Inf
    PW1 2   watered C   2   SIMA    829 Inf 0   829 Inf
    PW1 3   watered D   2   SIMA    829 Inf 0   829 Inf
    PW2 1   watered A   7   SIMA    829 Inf 0   829 Inf
    PW2 2   watered C   2   SIMA    829 Inf 0   829 Inf
    PW2 3   watered D   2   SIMA    829 Inf 3   829 Inf
    PW3 1   watered A   7   SIMA    829 Inf 0   829 Inf
    PW3 2   watered C   2   SIMA    829 Inf 2   829 Inf
    PW3 3   watered D   2   SIMA    829 Inf 0   829 Inf
    PW4 1   watered A   7   SIMA    829 Inf 2   829 Inf
    PW4 2   watered C   2   SIMA    829 Inf 3   829 Inf
    PW4 3   watered D   2   SIMA    829 Inf 2   829 Inf
    PW5 1   watered A   7   SIMA    829 Inf 3   829 Inf
    PW5 2   watered C   2   SIMA    829 Inf 0   829 Inf
    PW5 3   watered D   2   SIMA    829 Inf 0   829 Inf

更新

根据评论和更多的背景研究,我发现我实际上可以将数据表示为正确的审查数据:

    Plot ID Subplot Treatment   Column  Row Species Time    Event
    PS1 1   shelter A   7   SIMA    829 0
    PS1 2   shelter C   2   SIMA    829 1
    PS1 3   shelter D   2   SIMA    829 0
    PS2 1   shelter A   7   SIMA    829 0
    PS2 2   shelter C   2   SIMA    829 0
    PS2 3   shelter D   2   SIMA    829 0
    PS3 1   shelter A   7   SIMA    829 0
    PS3 2   shelter C   2   SIMA    829 0
    PS3 3   shelter D   2   SIMA    829 0
    PS4 1   shelter A   7   SIMA    829 0
    PS4 2   shelter C   2   SIMA    535 1
    PS4 3   shelter D   2   SIMA    829 0
    PS5 1   shelter A   7   SIMA    829 0
    PS5 2   shelter C   2   SIMA    829 0
    PS5 3   shelter D   2   SIMA    829 0
    PC1 1   control A   7   SIMA    535 1
    PC1 2   control C   2   SIMA    829 0
    PC1 3   control D   2   SIMA    535 1
    PC2 1   control A   7   SIMA    829 0
    PC2 2   control C   2   SIMA    829 1
    PC2 3   control D   2   SIMA    535 1
    PC3 1   control A   7   SIMA    152 1
    PC3 2   control C   2   SIMA    829 0
    PC3 3   control D   2   SIMA    829 0
    PC4 1   control A   7   SIMA    152 1
    PC4 2   control C   2   SIMA    120 1
    PC4 3   control D   2   SIMA    120 1
    PC5 1   control A   7   SIMA    92  1
    PC5 2   control C   2   SIMA    152 1
    PC5 3   control D   2   SIMA    829 1
    PW1 1   watered A   7   SIMA    829 1
    PW1 2   watered C   2   SIMA    829 0
    PW1 3   watered D   2   SIMA    829 0
    PW2 1   watered A   7   SIMA    829 0
    PW2 2   watered C   2   SIMA    829 0
    PW2 3   watered D   2   SIMA    829 1
    PW3 1   watered A   7   SIMA    829 0
    PW3 2   watered C   2   SIMA    120 1
    PW3 3   watered D   2   SIMA    829 0
    PW4 1   watered A   7   SIMA    120 1
    PW4 2   watered C   2   SIMA    829 1
    PW4 3   watered D   2   SIMA    152 1
    PW5 1   watered A   7   SIMA    829 1
    PW5 2   watered C   2   SIMA    535 1
    PW5 3   watered D   2   SIMA    829 0

然后我将此代码应用于:

    rsimafit <- survfit(Surv(Time, Event, type = c('right')) ~ Treatment, data = rsima)

    ggsurvplot(rsimafit, conf.int = TRUE, pval = TRUE, legend.labs=c("Control","Drought","Water+"), ggtheme = theme_bw(), legend.title = "Treatment", title ="Sidalcea malviflora", palette = c("gray47","orangered","deepskyblue"),xlim=c(0,838), ylim=c(0,1), xlab="Days Since Planting")

我得到以下输出: right censored plot

现在,我最大的问题是决定使用哪种最合适的模型:survdiff survregcoxph

我已经做过一些背景研究,但是我在统计模型或编程方面没有很强的背景-据我所知: survreg是参数化的 survdiff是非参数的 coxph是半参数的(不确定是什么意思),用于测试多种治疗方法以及它们之间的相互作用。此外,它们都输出相似的p值

我认为所有这些都使用某种类型的对数秩检验来与原假设进行比较,在我看来,原假设是可控制的?此外,我无法确定事后成对比较在这种情况下是否可行或适当。任何输入或指导将不胜感激。我已经阅读了许多其他有关stackoverflow,statsexchange和crossvalidated的示例,但是仍然很困惑。

1 个答案:

答案 0 :(得分:1)

survival package中的功能survreg()适合参数化加速故障时间(AFT)模型。 AFT模型是应用于生存时间(实际上是对数生存时间)的简单线性回归的类似物,并考虑了估计中的审查。由于这些都是参数化模型,因此,实际上,当您使用它们时,您就在假设生存时间的分布。

函数coxph()适合半参数Cox比例风险模型。这是危害函数的模型,并假定了危害量表中协变量的乘积效应。该模型并未假设您的生存时间有任何特定的分布,但确实做出了比例风险假设(即,风险等级中协变量的影响随时间恒定)。

函数survdiff()进行对数秩检验和Gehan-Wilcoxon检验(如果将参数rho设置为1)。这些测试测试特定群体(例如,男性与女性)的生存时间分布是否相等。对数秩检验等效于Cox模型的得分检验,其中您将组变量包括为协变量。