加载文件或程序集时出错 - 连接到系统的设备无法正常运行。 （HRESULT异常：0x8007001F）

Question

周末，我们的IT团队升级了我们的存储设备。我们现在在事件日志中看到以下消息：

Failed to initialize the AppDomain:/LM/W3SVC/3/ROOT/XP2

Exception: System.IO.FileLoadException

Message: Could not load file or assembly 'System.Web, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b03f5f7f11d50a3a' or one of its dependencies. A device attached to the system is not functioning. (Exception from HRESULT: 0x8007001F)

StackTrace:    at System.Reflection.RuntimeAssembly._nLoad(AssemblyName fileName, String codeBase, Evidence assemblySecurity, RuntimeAssembly locationHint, StackCrawlMark& stackMark, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks)
   at System.Reflection.RuntimeAssembly.nLoad(AssemblyName fileName, String codeBase, Evidence assemblySecurity, RuntimeAssembly locationHint, StackCrawlMark& stackMark, Boolean throwOnFileNotFound, Boolean forIntrospection, Boolean suppressSecurityChecks)
   at System.Reflection.RuntimeAssembly.InternalLoadAssemblyName(AssemblyName assemblyRef, Evidence assemblySecurity, StackCrawlMark& stackMark, Boolean forIntrospection, Boolean suppressSecurityChecks)
   at System.Reflection.RuntimeAssembly.InternalLoad(String assemblyString, Evidence assemblySecurity, StackCrawlMark& stackMark, Boolean forIntrospection)
   at System.Activator.CreateInstance(String assemblyName, String typeName, Boolean ignoreCase, BindingFlags bindingAttr, Binder binder, Object[] args, CultureInfo culture, Object[] activationAttributes, Evidence securityInfo, StackCrawlMark& stackMark)
   at System.Activator.CreateInstance(String assemblyName, String typeName)
   at System.AppDomain.CreateInstance(String assemblyName, String typeName)
   at System.AppDomain.InternalCreateInstanceWithNoSecurity(String assemblyName, String typeName)
   at System.AppDomain.InternalCreateInstanceWithNoSecurity(String assemblyName, String typeName)
   at System.Activator.CreateInstance(AppDomain domain, String assemblyName, String typeName)
   at System.Web.Hosting.ApplicationManager.CreateAppDomainWithHostingEnvironment(String appId, IApplicationHost appHost, HostingEnvironmentParameters hostingParameters)
   at System.Web.Hosting.ApplicationManager.CreateAppDomainWithHostingEnvironmentAndReportErrors(String appId, IApplicationHost appHost, HostingEnvironmentParameters hostingParameters)

我看到很多关于错误的帖子：

  

连接到系统的设备无法正常工作。 （例外   HRESULT：0x8007001F）

但他们主要处理的是无法登录的特定用户。

我们将应用程序池设置为使用域帐户并使用LoadUserProfile = True。我们还设置为使用25个工作进程和50个请求限制。我认为其中一些工作进程可能无法正确登录，或者网络存储可能正在丢弃某些连接。

对我可以检查的事情有任何想法吗？