如果我加载工作簿，请对其进行更改，然后将其另存为单独的文档，当我尝试在Excel中打开此新文档时出现错误。如果单击“是”（修复文件），则可以将其打开，并且所有数据均按预期存在。并非所有工作簿都发生这种情况。我很确定它与工作簿中的某些格式有关，但我不知道是哪一种格式。
如果我加载工作簿并且不进行更改，但是将其另存为单独的文档，则打开时不会出现错误。
查看新的（损坏的）文件和原始文件的content_type.xml，似乎Openpyxl没有使用与原始文件相同的ContentType / PartName。
代码：
import openpyxl
import time
wb_name = 'test.xlsx'
new_book = openpyxl.load_workbook(wb_name)
new_book.worksheets[2].insert_cols(3, 2)
output_file = "test-%s.xlsx" % time.strftime("%Y%m%d-%H%M%S")
new_book.save(filename=output_file)
原始文件的content_types.xml：
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<Types xmlns="http://schemas.openxmlformats.org/package/2006/content-types">
<Default Extension="bin" ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.printerSettings"/>
<Default Extension="rels" ContentType="application/vnd.openxmlformats-package.relationships+xml"/>
<Default Extension="xml" ContentType="application/xml"/>
<Override PartName="/xl/workbook.xml" ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.sheet.main+xml"/>
<Override PartName="/xl/worksheets/sheet1.xml" ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml"/>
<Override PartName="/xl/worksheets/sheet2.xml" ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml"/>
<Override PartName="/xl/worksheets/sheet3.xml" ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml"/>
<Override PartName="/xl/worksheets/sheet4.xml" ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml"/>
<Override PartName="/xl/theme/theme1.xml" ContentType="application/vnd.openxmlformats-officedocument.theme+xml"/>
<Override PartName="/xl/styles.xml" ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.styles+xml"/>
<Override PartName="/xl/sharedStrings.xml" ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.sharedStrings+xml"/>
<Override PartName="/xl/drawings/drawing1.xml" ContentType="application/vnd.openxmlformats-officedocument.drawing+xml"/>
<Override PartName="/xl/tables/table1.xml" ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml"/>
<Override PartName="/xl/charts/chart1.xml" ContentType="application/vnd.openxmlformats-officedocument.drawingml.chart+xml"/>
<Override PartName="/xl/charts/style1.xml" ContentType="application/vnd.ms-office.chartstyle+xml"/>
<Override PartName="/xl/charts/colors1.xml" ContentType="application/vnd.ms-office.chartcolorstyle+xml"/>
<Override PartName="/docProps/core.xml" ContentType="application/vnd.openxmlformats-package.core-properties+xml"/>
<Override PartName="/docProps/app.xml" ContentType="application/vnd.openxmlformats-officedocument.extended-properties+xml"/>
</Types>
损坏的文件的content_types.xml：
<Types xmlns="http://schemas.openxmlformats.org/package/2006/content-types">
<Default ContentType="application/vnd.openxmlformats-package.relationships+xml" Extension="rels"/>
<Default ContentType="application/xml" Extension="xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.sharedStrings+xml" PartName="/xl/sharedStrings.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.styles+xml" PartName="/xl/styles.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.theme+xml" PartName="/xl/theme/theme1.xml"/>
<Override ContentType="application/vnd.openxmlformats-package.core-properties+xml" PartName="/docProps/core.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.extended-properties+xml" PartName="/docProps/app.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet1.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet2.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table1.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet3.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table2.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet4.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table3.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet5.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table4.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet6.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table5.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet7.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table6.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet8.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table7.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet9.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table8.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet10.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table9.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet11.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table10.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet12.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table11.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet13.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table12.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet14.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table13.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet15.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table14.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet16.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table15.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet17.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table16.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet18.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table17.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet19.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table18.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.worksheet+xml" PartName="/xl/worksheets/sheet20.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.table+xml" PartName="/xl/tables/table19.xml"/>
<Override ContentType="application/vnd.openxmlformats-officedocument.spreadsheetml.sheet.main+xml" PartName="/xl/workbook.xml"/>
</Types>